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Malyar, R

More generally, this review not only presents genetic dependencies typically present in most tumors but also reveals unique characteristics of GBM in comparison to other tumors

The likelihood of pre-existing resistant clones is shaped by tumor size, baseline mutational burden, fitness costs, and microenvironmental constraints, making therapeutic failure an expected evolutionary outcome under strong selective pressure

In the future, the development of responsive nanomaterials should focus on the deep integration of multiple response mechanisms and biomimetic design, aiming to develop nanomaterials with multi-responsiveness