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When the nerve becomes inflamed, symptoms can include: Shooting or radiating pain down the leg Burning or electric sensations Numbness or tingling Weakness in the leg or foot Pain that worsens with sitting What is often overlooked is that irritated nerves become inflamed at a microscopic level

AI and AI-assisted tools statement During the preparation of this manuscript, the AI tool ChatGPT (GPT-5, released 2025-08-07) was used to generate Figure 1 and the Graphical Abstract and to improve the readability and language of the manuscript

These processes are critical for sensory transduction and are all disrupted in inherited disorders of hearing in humans [79]

M., Linares, E., Santos, C