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[The Working Group noted that these studies may be of limited relevance to the key characteristic of carcinogens induces chronic inflammation.] Altered cytokine levels TNF levels, measured via ELISA, in the brain tissue of Swiss albino mice exposed subcutaneously to aspartame in saline solution at doses of 22.5 or 45 mg/kg were elevated relative to levels in controls exposed intraperitoneally to saline solution at 0.1 mL/mouse (Abdel-Salam et al., 2012a)

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[DOI] [PubMed] [Google Scholar] 8.Kotb M., Mudd S.H., Mato J.M., Geller A.M., Kredich N.M., Chou J.Y., Cantoni G.L

Accordingly, during an immune challenge, substance P produced by immune and non-immune cell types can function as a potent chemoattractant and promote the inflammatory responses of a diverse range of cells including macrophages, dendritic cells, lymphocytes and eosinophils (OConnor et al., 2004)