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The elevation of SMAD signaling, prompted by hADSC-Exos at both mRNA and protein levels, results in the downregulation of essential apoptosis-related genes, such as Fas, Fas ligand, caspase-3, and caspase-8

Under a sustained environmental stress, ROS are produced over a long time, and thus significant damage may occur to cell structure and functions and may induce somatic mutations and neoplastic transformation [9, 10]