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Evidence for its role in mitogen-activated protein kinase activation and receptor internalization *

doi: 10.3892/ijmm.2021.4954 33

The HIF-1 activation triggers a proangiogenic host cell response with increased levels of vascular endothelial growth factor (VEGF) and up-regulation of genes for the GLUT-3 and glycolytic enzymes (Kempf et al., 2005) thereby inhibiting apoptosis