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Description

In MPTP-induced dopaminergic neurotoxicity in mice, two structural analogs of CDDO (TP-319 and TP-500), which are produced by the cyclization of squalene, have been shown to increase bloodbrain barrier permeability and provide protection against inflammation and oxidative stress [118]

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Arch Intern Med 1981;141 (11):15434

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The intralobular zonation of drug-induced metabolizing enzymes is clearly associated with patterns of toxicity

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EASL Clinical Practice Guidelines on sclerosing cholangitis

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