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Polyphenols have the ability to hinder pro-inflammatory substances including NF-B, COX-2, and iNOS, and decrease the generation of cytokines such as TNF-, IL-1, and IL-6 ( 3.3 Modulation of signal transduction pathways Polyphenols exert an impact on various signaling pathways, encompassing

However, ferroptosis plays a key role in the pathogenesis of several CCVDs, and studies have shown that ferroptosis is closely related to AS, MI, HF, DCM, hypertension, and IS (Wu et al., 2021a)