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211,212,213 PD-L1, a major ligand for the immunosuppressive receptor PD-1, serves as a pivotal immune checkpoint that modulates the activation threshold of immune cells in response to antigens

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Some drugs, including proton pump inhibitors (PPIs) and histamine 2 receptor antagonists (H2RAs) are acid-inhibiting, impairing the release of dietary B12 from food proteins, thus producing risk of B12 deficiency (Lam et al., 2013)