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Description

In Synechocystis , exposure to gentamicin stimulated GSH synthesis, whereas a gshB mutant was killed by the drug, despite carrying a resistance gene

This study also found that anti-doxorubicin produced inflammation and oxidative stress in the kidneys, and that doxorubicin plus apigenin increased resistance to doxorubicin in breast cancer cells via the JAK/STAT signalling pathway (162)

10.3390/ph15030312 130 VaezH.NajafiM.RameshradM.ToutounchiN

Its small molecular weight (~390 Da) supports cellular uptake and is reported to enable direct DNA / chromatin interaction at gene promoter regions, consistent with the broader Khavinson bioregulator hypothesis