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3.2.6 O-GlcNAcylation O-GlcNAcylation is another type of PTM, which involves the addition of N-acetylglucosamine (GlcNAc) to Ser or Thr residues (Figure 4D)

Toh SQ, Glanfield A, Gobert GN, Jones MK

Notably the association between GGT and cardiovascular mortality was not significant in the subgroup of Asian participants [relative risk =1.76 (0.763.30)] (36)

demonstrated that macrophages can absorb extracellular lactate to promote the lactylation of high mobility group box-1 (HMGB1), which is subsequently secreted via exosomes, increasing endothelial permeability and inducing further endothelial barrier dysfunction [163]