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& Khuntikeo, N

S., Leboeuf, R

Melatonin, a hormone primarily synthesized in the pineal gland that delays aging, resists oxidation, and improves sleep, is considered a positive regulator of Nrf2 (112114)

The actions of SOD1 are varied such as modifying cellular respiration, scavenging excessive O 2 - , posttranslational modifications, and energy metabolism (Saccon et al., 2013)