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Graphical Abstract Similar content being viewed by others Introduction The tight junction-connected, non-fenestrated brain capillary endothelial cells in cross-talk with the neighboring pericytes and astroglial endfeet create the dynamic anatomical and functional unit called as bloodbrain barrier (BBB) [1]

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Peer-reviewed GHK-Cu research includes a substantial mechanistic literature (cell-culture, gene-expression-profile, and animal studies), a smaller clinical literature in topical-skincare applications including the Miller 2006 controlled post-laser-resurfacing trial, and limited published human data on injectable or oral administration routes