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However, glutathione deficiency has been strongly associated with loss of function with aging and the onset of diseases

Therefore, ferroptosis inducers include compounds that inhibit system Xc - (erastin, imidazole ketone erastin (IKE), sulfasalazine) 7,9 , compounds that directly inhibit GPX4 (RSL3, ML-210) 8 , and compounds that inhibit glutathione synthesis (buthionine sulfoximine) 8

Research suggests it helps balance the immune response and may reduce biomarkers like C-reactive protein, though liposomal delivery is often required for meaningful absorption

Therefore, we hypothesize that FEV inhibits transcription of SLC7A11 by direct promoter interaction