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DOI: 10.1002/9780470744307.gat166

These modifications protect the peptide from exopeptidase-mediated degradation aminopeptidases at the N-terminus and carboxypeptidases at the C-terminus resulting in substantially improved metabolic stability in biological matrices

Dhuria SV, Hanson LR, Frey IIWH

Conducting studies with oral formulations might require more foundational research to establish optimal parameters, adding layers of complexity to experimental design