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Trends Mol Med (2021) 27(9):895906

This metabolic flexibility is critical during times of glucose scarcity or high functional demand

Figure 46 ) are impaired

75,76 MyD88 also activates the transcription factor IRF5, which directly induces the genes encoding IL-12 subunits p40, IL-12p35, and IL-23p19, thereby enhancing M1 polarization