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Herberts proposed model, illustrating the biochemical, metabolic, and clinical changes that occur as B12 levels move from repletion to depletion, eventually leading to clinical vitamin B12 deficiency: The 4 Stages of B12 Deficiency In Detail Heres a more detailed description of all B12 deficiency stages: Stage 1: Early Serum Depletion This marks the beginning of B12 deficiency

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By helping to prevent macrocytic anemia, B12 ensures that red blood cells are the correct size and shape to efficiently transport oxygen to starving tissues, alleviating the sensation of air hunger