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Mouse Nrf2, Kelch-like ECH-associated protein 1 (Keap1), and NAD(P)H:quinone oxidoreductase 1 (NQO1) ELISA kits were purchased from CUSABIO (Wuhan, China)

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Excessive and chronic activation of mast cells lead to neuroinflammation and neurodegeneration

Although emerging therapies such as glucagon-like peptide-1 (GLP-1) analogues (e.g., semaglutide) and dual glucose-dependent insulinotropic polypeptide (GIP)/GLP-1 receptor agonists (e.g., tirzepatide) have received clinical approval for obesity management, substantial demand persists for alternative or adjunctive therapies employing distinct mechanisms