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IGF-1 as the Research Readout Across the CJC-1295 literature, IGF-1 is the marker most often used to gauge a response, and for a clear reason: where growth hormone itself is secreted in short bursts and clears quickly, circulating IGF-1 integrates growth-hormone exposure over time, so it reflects sustained activation of the axis more stably than a single GH measurement

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(Neither the FDA nor HHS responded to ProPublicas requests for more information.) But several regulatory shortcuts exist and, ultimately, Kennedy could simply declare the ingredients are legal