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J Intercult Ethnopharmacol, 6 , 280283

Selenoprotein polymorphisms are a risk factor for the development of systolic heart failure (HF) and peripheral atherosclerosis but prevent the development of abdominal aortic aneurysm (AAA)

The MitoCHAC1 nucleotide sequence was designed such that the initiating codon was replaced with the coding sequence for the first 25 amino acids of the ornithine transcarbamylase leader sequence 89 to facilitate targeting of exogenous CHAC1 to the mitochondrial matrix