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Description

Pharmaceutics 14:1251

Mounting evidence demonstrated that sIgA and the polymeric immunoglobulin receptor (pIgR) play a pivotal role in immune homeostasis by limiting the access of microbial and environmental antigens into the body, maintaining the integrity of the epithelial barrier, and shaping the composition of the commensal microbiota (100102)

Upon binding to the erythropoietin receptor (EpoR, located on the surface of erythroid progenitor cells), EPO activates Jak2/STAT5, Ras/Raf/MEK/ERK and PI3K/Akt signaling pathways [41, 42] with consequent downstream recruitment of GATA-1 transcription factor [43], a master regulator of erythropoiesis critically affecting all aspects of cell survival and proliferation