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ECM Remodeling: Collagen, Elastin, GAGs# In dermal fibroblasts, GHK-Cu upregulates type I and III collagen, elastin, decorin, and glycosaminoglycan synthesis while simultaneously activating matrix metalloproteinases (MMP-1, MMP-2) and their tissue inhibitors (TIMPs)

Prostaglandin is one of the key ingredients in the inflammatory response

Like any injection, there is some discomfort during the treatment, but it is minimal

Materials and methods Primary human hepatocyte isolation Primary human hepatocytes (PHH) were prepared from nontumorous tissues obtained from freshly resected human livers of different donors (PHH Ctrl, n = 4) or explanted livers of WD patients (PHH WD, n = 2) via a two-step perfusion protocol as previously described [8]