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Confirmation of a direct role for GSTP1 in chemotherapy response is important, not only in the prediction of response to platinum-based chemotherapy, but as a candidate response biomarker for new generation chemotherapy drugs, designed to exploit increased GSTP1 expression in tumours relative to surrounding normal tissues

GLS encodes kidney-type glutaminase (KGA) and its C-terminal truncated splice variant glutaminase C (GAC), the predominant form of GLS expressed in many cancers, while GLS2 is expressed as only one active isozyme, liver-type glutaminase (LGA)

Both routes end in growth hormone release, but they start from different doors

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