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The LC-MS system was controlled by Masslynx software

The images (Figure 5) showed a time-dependence penetration into the skin, as initially, the particles tended to penetrate between the corneocytes isles (green stained) and, further application time, the vesicles tended to penetrate via intercellular lipids and follicular regions (red stained) until a maximum depth of 60 m [57]

In both in vitro (0.5 M for 24 h) and in vivo (141 mol/kg/day for 14 days) settings, SF mitigated high glucose-induced apoptosis by inhibiting the upregulation of apoptotic markers and the downregulation of antiapoptotic maker Bcl-2 protein in hippocampal neurons exposed to high glucose (126)

Spatial heterogeneity was assessed by 1) the variability of LS calculated as the difference between the maximum and minimum LS divided by the maximum LS and 2) the coefficient of variation (CoV) calculated as the standard deviation of LS at each MRE slice divided by the respective mean LS