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While demonstrating biological plausibility and mechanisms, in vitro conditions poorly replicate complex in vivo environment

MYC functions as a central regulator of glutamine metabolism in prostate cancer by repressing miR-23a/b, thereby relieving the inhibition of mitochondrial GLS and promoting glutaminolysis, particularly in androgen-independent PC-3 cells (36, 37)

Targeted suppression of ferroptosis using compounds like ferrostatin-1 and liproxstatin-1 protects melanocytes from demise, thereby ameliorating vitiligo pathology (133)

In a human double-blind placebo-controlled trial on the effect of chronic -carotene supplementation (6 months) on the response to acute ASA injury (12 subjects, single oral dose of 650 mg of ASA dissolved in 60 mL of water), endoscopic control found mucosal lesions three hours post-administration in supplemented patients, as well as in the control group [248]