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Though you don't want to test her patience any further, or come off as any more of a basket case than you already have

Likewise, in murine macrophages, the activated 7nAChR can mediate Jak2-STAT3 activation and then can induce the phosphorylation of STAT3, which subsequently downregulates pro-inflammatory cytokines (e.g., IL6, IL12, and TNF-) [133]