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First, normal aging is associated with the progressive dysregulation of iron homeostasis, often leading to iron accumulation in vulnerable brain regions such as the hippocampus and substantia nigra (52)

The high antiradical efficacy of the flavonoid complexes is due to the ability of chelated metal ion to operate as a superoxide scavenger with dismutating activity, in accord with the following reactions: (n+1)+ + 2 n+ + 2 (10) n++ 2 + 2H+ (n+1)+ + H22 (11) Apparently, the flavonoid molecules are able to react with metal ions directly in blood stream or tissues

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