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Consequently, nox1 mutants display an overall marked increase in the levels of free amino acids, including L-arginine, a precursor of NO 24 (Supplementary Fig

[DOI] [PMC free article] [PubMed] [Google Scholar] 178.Luke N., Hillier K., Al-Samkari H., Grace R.F

This effect is mediated by GSH-dependent conjugation and export of anticancer drugs, diminishing their intracellular concentrations and therapeutic efficacy (5053)