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Some authors indicated that patients with GD had suffered on average more stressful episodes than control subjects, but other similar studies failed to show this relationship (77-80)

27,28,29 But it was not until the discovery of signaling mediators small (Sma) in Caenorhabditis elegans and mothers against decapentaplegic (Mad) in Drosophila melanogaster that the homologous small mothers against decapentaplegic (SMAD) proteins were identified as the canonical signal transducers of TGF- signaling in humans in 1996

People with malabsorption or gastrointestinal disease Conditions such as pernicious anemia, post-gastric surgery states, celiac disease, long-term proton pump inhibitor use, or other malabsorption syndromes reduce absorption of B12 from food and pills

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