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They found that: using bupropion makes it 52% to 77% more likely that a person will successfully stop smoking for six months or more (equal to five to seven more people successfully quitting for every 100 who attempt to quit) nortriptyline also improves the chances of success bupropion increases unwanted side effects, particularly those relating to mental health (such as anxiety and insomnia), which increases the chance that people will stop taking the medication people taking bupropion are as likely to quit smoking as those using nortriptyline or NRT people using varenicline are more likely to quit smoking than those using bupropion