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In addition, probiotics can regulate the activity of immune cells, including T cells and macrophages, contributing to a balanced immune response that protects the BBB (Rastogi and Singh, 2022)

Also, glutamate-derived glutamine production through GS activity could be another mechanism to overcome glutamine addiction and to promote resistance to glutaminolysis inhibitors [85]

revealed that endogenous metabolites of vitamin E, particularly -13-COOH, exert anti-inflammatory effects by directly inhibiting 5-lipoxygenase (5-LO), a key enzyme in leukotriene biosynthesis