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10.1016/j.ijbiomac.2023.126835 156 KimH.-J.ZhangK.MooreL.HoD

Because clinical studies remain limited, the complete adverse-effect profile has not been established

By contrast, in compound use, short-term use does not produce acute toxic reactions, but long-term use can cause damage to the liver, kidneys, and other organs

Although animal studies revealed that vitamin E alleviated the level of oxidative damage associated with diabetes, the alpha-tocopherol/beta-carotene (ATBC) trial in male smokers taking 50 mg/day synthetic vitamin E showed no effect on mortality or macrovascular complications (in the coronary or peripheral arteries) in participants with type 2 diabetes (Kataja-Tuomola et al