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Indeed, homocysteine neurotoxic properties have been attributed to NMDA receptor stimulation, auto-oxidation elevating oxidative stress, mitochondrial complex I inhibition, and allosteric D2 receptor antagonism (88)

Metformin is a commonly used drug for the clinical treatment of T2DM, which improves the sensitivity and utilization of insulin in body tissues and reduces the occurrence of adverse events such as hypoglycemia and obesity (Pernicova and Korbonits, 2014)

In rats with collagen-induced arthritis (CIA), BM-MSC transplantation has been shown to inhibit the expression of cytokines associated with bone destruction, alleviate joint inflammation, and inhibit synovial proliferation and cartilage destruction

It catalyzes the reductive transfer of an amino group from aspartate to -ketoglutarate to yield oxaloacetate and glutamate