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Interruption of Triacylglycerol Synthesis in the Endoplasmic Reticulum Is the Initiating Event for Saturated Fatty Acid-Induced Lipotoxicity in Liver Cells

Mao 1 , Todd Kellogg 1 and Julie Heimbach 1 , (1)Mayo Clinic, (2)Johns Hopkins, (3)Mayo Clinic, Rochester, MN, (4)Mayo Clinic Arizona, Phoenix, AZ Background: The prevalence of obesity and metabolic syndrome (MS) is rising dramatically among liver transplant (LT) candidates, many of whom have NASH

This service enables systems-level insights into the regulatory roles of glutarylation in metabolism, signaling, and disease mechanisms

While often used interchangeably in discussion, their biochemical properties and primary research applications can differ