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In TMD2, two studies suggest that position N 2.61 is critical for binding in TAS2R1 (Singh et al., 2011) and TAS2R46 ( 7.39 is implicated in binding to TAS2R46 (E265) and TAS2R1 (I263) ( 5.43 is implicated in binding in TAS2R16 and E 5.46 in TAS2R1 ( 7.32 was crucial for metal ion binding (Wang et al., 2019)