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Food intake in animal studies remained unchanged despite the compound producing significant fat loss

Safety: Its important to note that while AOD-9604 demonstrated excellent safety and tolerability, the clinical development program was ultimately discontinued because efficacy for weight loss did not meet regulatory approval standards

In 2013, a clinical trial comparing phentermine as monotherapy or as part of a combined therapy, took place and resulted in a weight loss of 5.1% at 28 weeks follow-up period in favor of the combined phentermine/topiramate group.(see Table 10) Table 10