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This study demonstrated that the plasma concentration of thiosulfate in normal males is about 10 mg/l, and that excretion amounts to approximately 3 mg/day, compared with findings of Srbo & Ohman (1978) who discovered a renal excretion value of 31.7 ( 12.8) mmol/24 h (7.9 ( 3.2) mg/l per 24h)

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Summary: Vitamin B12 supplements can be taken at any time of day, as absorption mechanisms function consistently throughout the 24-hour cycle, with consistency being more important than specific timing