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Prolonged reduction in physical activity may lead to skeletal muscle waste, which may cause several adaptive changes, including reduced type I fibers and oxidase capacity, muscle fiber atrophy, and decreased muscle capillaries (78)

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However, we acknowledge that all postmortem brain samples used in this study were obtained from male subjects due to limitations in available matched tissue

The result is poor regrowth and a conclusion (eventually) by the patient and doctor that steroid injections didnt work. The patient then often moves on to strong and stronger medications with more and more potential side effects