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NKG2D-mediated cytotoxicity toward oligodendrocytes suggests a mechanism for tissue injury in multiple sclerosis

Despite being originally classified as a non-essential amino acid [32] in healthy individuals [33], abundant evidence suggests that glutamine is essential in specific stress situations such as severe illness, trauma, and overtraining [9, 34,35,36,37,38]

Therefore, we investigated the role of PAF C-16 intracellular signaling pathway components such as PLC, cPLA 2 and different second messengers in PAF C-16 induced growth inhibition of intracellular M