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AATD-1 is typically caused by a single-letter mutation in DNA, making it a good candidate for base editing

Its association with various metabolic irregularities, such as the onset of atherosclerosis, high lipid concentration, obesity, and liver lipid accumulation, is widely recognized (81)

Dnmt1, Dnmt3a and Dnmt3b) and the demethylases teneleven translocation (TET) methylcytosine dioxygenase (Tet13), and the methyl-CpG-binding protein 2 (MeCP2)