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An inherited condition called alpha-1 antitrypsin (AAT) deficiency enlarges the peril of early-onset emphysema, particularly among smokers, as highlighted in Yale Medicines Fact Sheets. Heart disease : As nicotine raises blood pressure and increases heart rate it contributes to a higher risk of heart attacks, stroke, and other cardiovascular problems

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A2023 systematic reviewsuggested that CBD, either alone or paired with tetrahydrocannabinol (THC), may improve insomnia and sleep