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Neurological aspects of cobalamin deficiency

In KRAS-mutant tumors, YAP1 activation mediated by RASSF1A deficiency has been identified as the core mechanism through which cancer cells evade direct KRASG12C inhibitorinduced killing and develop acquired resistance [88, 89]

The collective goal is to elevate the patients quality of life at every turn of the diseases trajectory, while ensuring that caregivers are encircled with the support and resources required to deliver the most empathetic and effective care