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After 24 h of berberine administration, the hyperphosphorylation of tau at Ser198/199/202, Ser396, Ser404, Thr205, and Thr231 was significantly reduced (Yu et al., 2011)

Studies have shown that IF significantly enhances GH secretion and elevates insulin-like growth factor binding protein 1 (IGFBP1) levels up to fivefold [42], thereby modulating IGF-1 bioavailability and enhancing autophagy, lipolysis, and muscle preservation [42, 43]

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Traditional over-the-counter solutions like NSAIDs or topical creams may provide short-term relief, but they rarely address the underlying issues