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Rationale for Clinical Trials Based on Preclinical Data The proposed clinical trials rely on a large amount of preclinical data: Mesenchymal Stem Cells: The use of SS-31 in aged bone marrow mesenchymal stem cells resulted in a significant improvement in mitochondrial function, which allowed for a 35% increase in ATP and a 40% decrease in the level of ROS (reactive oxygen species)

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Jaswal SM, Granados Samayoa JA, Kam JWY, Randles D, Heine SJ, Handy TC