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The premise underlying the leaky gut hypothesis is that physiologic stressors such as anxiety, intensive exercise, or dietary components such as emulsifiers increase intestinal mucosal paracellular permeability, enhancing entry of pathogenic bacteria and bacterial toxins into the systemic circulation, provoking systemic inflammation and triggering numerous diseases

Transepithelial transport processes at the intestinal mucosa in inflammatory bowel disease

These findings further established immunotherapy as a critical tool for TNBC treatment ( Table 5 )

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