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Prog Neuro-Psychopharmacology Biol Psychiatry 46:200206 Chapple IL (1997) Reactive oxygen species and antioxidants in inflammatory diseases

Numerous clinical reviews have called for further research to confirm anecdotal and case findings [5,6,81,82], as early evidence of positive effects of the KD on schizophrenic and bipolar symptoms warrant further investigation and require confirmation through controlled clinical trials

Remarkably, it has been shown that blocking gliotransmission diminished the accumulation of sleep pressure (Halassa et al., 2009), as evidenced by changes in slow wave activity of the electroencephalogram (EEG) during Non-rapid eye movement (NREM) sleep and prevented sleep loss associated with cognitive deficit/dysfunction (Halassa et al., 2009)

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