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Riboflavin contributes to normal energy-yielding metabolism, the protection of cells from oxidative stress, the maintenance of normal skin, and the normal function of the nervous system

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Consequently, mitochondrial metabolism and signaling including the UPR mt have been implicated in integrating nutrient- and microbiota-derived signals in the intestinal stem cell niche 8 , critically affecting the regenerative capacity of the epithelium under homeostatic and disease conditions