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Fernandez DR, Telarico T, Bonilla E, Li Q, Banerjee S, Middleton FA, Phillips PE, Crow MK, Oess S, Muller-Esterl W, Perl A: Activation of mammalian target of rapamycin controls the loss of TCRzeta in lupus T cells through HRES-1/Rab4-regulated lysosomal degradation

Thus, our data suggest downmodulation of CCR2 as a possible compensatory mechanism in response to sustained overproduction of CCL2 or continuous trafficking of CCR2 + cell into tissues (82)