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ER and mitochondria are two pivotal organelles involved in the function and survival of -cells ( In vivo and in vitro studies have highlighted distinct or combined role of ER stress and mitochondria dysfunction in -cell functionality ( Figure 2 As highlighted in previous sections, transcriptome studies on both human and mouse islets and -cells, as well as polygenic and monogenic forms of DM have provided compelling evidence on the importance of ER stress and UPR in -cell dysfunction and diabetes

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Under GCP, selecting the right patients to participate ensures that those who enroll are appropriate candidates for the specific trial, minimizing risks and maximizing the potential for beneficial outcomes

M., Canas, P