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These findings suggest the need for clinical trials to evaluate semaglutides potential for TUD treatment, the researchers wrote, noting that their study has several methodological shortcomings, including potential documentation bias, missing data and residual founding

Bibcode:2016PLoSO..1153310T

Mediators produced by the injured epithelium and the local immune cells drive airway remodelling, which involves subepithelial fibrosis due to increased ECM deposition, and airway smooth muscle thickening caused by smooth muscle cell hyperplasia and/or hypertrophy (1)