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These unique metabolic characteristics of immune cells are mainly reflected in the different metabolic patterns of immune cells during different cellular states, such as, quiescence, infection, or tumorigenesis [44, 46].For example, T cells exhibit completely different metabolic patterns depending on their activation state, for example, naive T cells have a minimum glycolytic rate and a minimum glutamine metabolism to maintain biosynthetic pathways for survival, whereas Teff cells have an increased glycolytic rate, and elevated glutamine metabolism, which enable the synthesis of proteins and nucleotides to meet the needs of rapidly proliferating tumor cells [47, 48]

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Eur Respir J 50:1701162 Lu Z, Huang W, Wang L et al (2018) Exhaled nitric oxide in patients with chronic obstructive pulmonary disease: a systematic review and meta-analysis